教員について

 専門分野

分子病態栄養学

－ 分子細胞生物学、分子栄養学、病態生化学、神経栄養科学

 担当科目

学部 － 分子栄養学、食品疾病予防学、他

大学院－ 食品成分化学特論、食品成分化学演習、他

脳卒中ラット由来神経細胞のアポトーシス誘導

 研究課題

「食品成分の疾病予防および新規生理機能に関する分子解析」

• 食品成分の動脈硬化や脳卒中に対する予防作用と分子機構
• 植物由来微量成分の血管内皮細胞の障害に対する予防特性
• アストロサイトの神経細胞への栄養供給の機構と脳卒中予防
• 脳タイトジャンクションの分子調節と食品成分の脳への輸送調節

炎症刺激したTHP-1細胞のROS産生

 原著論文および総説論文

• 2018年～
  Yamagata K,Izawa Y, Onodera D, Tagami M.

  Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells.
  Molecular and Cellular Biochemistry 441(1)9-19 (2018) doi: 10.1007/s11010-017-3171-1.

• Yamagata K.

  Do coffee polyphenols have a preventive action on metabolic syndrome associated endothelial dysfunctions ? an assessment of the current evidence.
  Antioxidants7(2). (2018) pii: E26. doi: 10.3390/antiox7020026. (Review)

• 2017
  Yamagata K,Takahashi N, Akita N, Nabika T. .

  Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
  Journal of Neuroinflammation 14:176 (2017) doi: 10.1186/s12974-017-0949-8.

• Yamagata K.

  Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease.
  Lipids in Health and Disease. 16(1):118. (2017) doi:10.1186/s12944-017-0514-6. (Review)

• Suzuki S, Nakashima N, Kageyama M, Yamagata K(SS and KY equally contributed).

  A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1β inendometrial epithelial cells.
  Reproductive Biology. 17 (3) p259-267 (2017)

• Yamagata K, Fujiwara A, Onodera D, Tagami M. Lutein regulates the expression of apoptosis-related genes and stem cell markers in A549 human lung cancer cells.

  Natural Product Communications 12(6) p897-900 (2017)

• 2016
  Yamagata K,Sone N, Suguyama S, Nabika T.

  Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
  International Journal of Experimental Pathology (IJEP) ) 97(2) p97-106 (2016)

• Yamagata K, Suzuki S, Tagami M.

  Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence.
  Prostaglandins, Leukotrienes & Essential Fatty Acids (PLEFA)) 104 (6) p11-18 (2016)

• 2015
  Yamagata K, Yajie X, Suzuki S, Tagami M.

  Epigallocatechin 3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFα-stimulated human endothelial cells.
  Phytomedicine 22 p431-437 (2015)

• Yamagata K, Tagami M, Yamori Y.

  Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. (REVIEW)
  Nutrition 31 p28-37 (2015)

• 2014
  Yamagata K, Yamamoto M, Kawakami K, Ohara H, Nabika T.

  Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
  Neuroscience 267 p277-285 (2014)

• Yamagata K, Tusruta C, Ohtuski A, Tagami T.

  Docosahexaenoic acid decreases TNF-α-induced lectin-like oxidized low-density lipoprotein receptor-1 expression in THP-1 cells.
  Prostaglandins, Leukotrienes & Essential Fatty Acids (PLEFA) 90 p125-132 (2014)

• 2013
  Yamagata K, Nakayama C, Suzuki K.

  Dietary β-carotene regulates interleukin-1β-induced expression of apolipoprotein E in astrocytes Isolated from stroke-prone spontaneously hypertensive rats.
  Neurochemistry International 62 p43-49 (2013)

• Yamagata K, Tanaka N, Suzuki K.

  Epigallocatechin 3-gallate inhibits 7-ketocholesterol-induced monocyte endothelial cell adhesion. Microvascular Research p25-31 (2013)

• 2012
  Yamagata K, Tagawa C, Matsufuji H. Chino M.

  Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells.
  The Journal of Nutritional Biochemistry 23 p929-936 (2012)

• Yamagata K.

  Pathological alterations of astrocytes in stroke-prone spontaneously hypertensive rats under ischemic conditions.(REVIEW)
  Neurochemistry International 60 p91-98 (2012)

（以下多数）

 著書

• 2018年～
  Yamagata K. .

  Metabolic syndrome: preventive effects of dietary flavonoids.
  Book title; Studies in Natural Products Chemistry (Bioactive Natural Products)
  Publishier; Elsevier, in press 2018

• Yamagata K.

  Insight into dietary epigallocatechin-3-gallate for endothelial dysfunction.
  Book title; Advancements in Endothelial Dysfunction Research
  Publishier; Nova Science, in press 2018

• Yamagata K.
  2017

  Preventive properties of green tea catechins against metabolic syndrome.
  Book title; Epicatechin: Sources, Effects and Research
  Publishier; Nova Science (2017 Chapter 2 p43-p69) ISBN: 978-1-53611-794-3.

• Yamagata K.

  Carotenoids regulate endothelial functions and reduce the risk of cardiovascular disease.
  Book title; Carotenoids,Editer: Dragan Cvetkovic Capter
  Publishier; Intech (2017 Chapter 7 p105-p121) ISBN 978-953-51-3211-0

• Yamagata K.

  Endothelial protective effects of dietary phytochemicals, focus on polyphenols and carotenoids.
  Book title; Studies in Natural Products Chemistry. Volume 55 (Bioactive Natural Products) Editors: Atta-ur-Rahman
  Publishier; Elsevier (2017 Chapter 10 p323-350) ISBN: 978-0-444-50588-0.

• 2016
  Yamagata K.

  Role of scavenger receptors in the development of atherosclerosis and the preventative effects of dietary components.
  Book title; Advances in Medicine and Biology. Volume 108 Editors: Leon V. Berhardt,
  Publishier; Nova Science Publishers, Inc. (2016 Chapter 7 p127-151).

• Yamagata K.

  Protective effects of docosahexaenoic acid on vascular endothelial dysfunction and cardiovascular disease.
  Book title; Docosahexaenoic Acid (DHA): Properties, Function and Health Effects.Editors: Alfonso Vargas,
  Publishier; Nova Science Publishers, Inc. (2016 Chapter 4 p119-140)

• Yamagata K.

  Cerebral ischemia induces neuronal vulnerability and astrocytic dysfunction in stroke-prone spontaneously hypertensive rats.
  Book title; Ischemic stroke - updates. E. Edited by Bernhard Schaller (University of Southampton,UK,University of Lille, France).
  Publishier; Intech. (2016 Chapter 3 p43-58) ISBN 978-953-51-2713-0.

• Yamagata K.

  Stroke-prone spontaneously hypertensive rats: insights on neuronalvulnerability and astrocytic abnormalities on stroke.
  Book title; Advances in Medicine and Biology. Volume 96, Editors; Leon V. Berhardt,
  Publishier; Nova Science Publishers, Inc. (2016 Chapter 8 p115-132) ISBN 978-1-6348-506-9.

• 2014
  Yamagata K, Tagami M.

  Prevention of ischemia-induced neuronal apoptosis by vitamin E in stroke-prone spontaneously hypertensive rats– cellular mechanisms.
  Book title; Bioactive nutraceuticals and dietary supplements in neurological and brain disease: Prevention and Therapy. Editors; Ronald Ross Watson & Victor R. Preedy.
  Publishier;Elsevier, (2014 Chapter 4 ) ISBN 978-0124114623

• 2012
  Yamagata K.

  Ischemic neurodegeneration in stroke-prone spontaneously hypertensive rat and its prevention with antioxidants.
  Book title; Advances in the preclinical study of ischemic stroke.
  Publishier;Intech (2012 Chapter 1 p1-20 ) ISBN 978-953-51-0290-8

• Yamagata K, Yamori Y.

  Tocopherol: Sources, uses and health bene fits: Effect of tocopherol on the ischemia reperfusion injury of the brain.
  Book title; Nutrition and Diet Research Progress Series Editors; Angel Catala (2012 Chapter 12 p193-205)
  Publishier; Novo Science Publishers

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